$B2;3ZNEK!;N!"%T%"%K%9%H!!@>B $B0e3XGn;N!!Bg;3Gn9T@h@8!!BPCL(B
$B!V?4$NJ?0B$H2;3ZNEK!!J0BB)$N;~$r5a$a$F!K!W!!(B 2009.9/27$B!JF|!K(B



$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B$B!!(B$B!!(B

$B!!(B$B!!(B

$B!!(B



$B2;3ZNEK!;N!"%T%"%K%9%H!!@>B $B0e3XGn;N!!Bg;3Gn9T@h@8!!BPCL(B
$B!V?4$NJ?0B$H2;3ZNEK!!J0BB)$N;~$r5a$a$F!K!W(B
$BF|;~!'(B2009.9/27$B!JF|!K(B
$B>l=j!'Bg;3=!GlElMN0e3X5-G04[(B





$B@83h$Ne(BQOL$B!J(Bquality of life$B!K$H4AJ}0e3X(B

$B-!(BQOL$B$NJQ2=!=Bg3XIB1!4AJ}%/%j%K%C%/$G$ND4::(B
$B!!7DXf5A=NBg3XIB1!4AJ}%/%j%K%C%/$NNO@P@i9aBe;a$i$O!"4AJ}<#NE$,A4?ME*0eNE$G$"$k$3$H$r=E;k$7!"$=$N(BQOL$B!J(Bquality of life)$B$KBP$9$kI>2A$K$D$$$F!"(B
$B=>Mh$N<@45JL$ND4::$G$O$J$/!"<@45$NOHAH$_$r>h$j1[$($?D4::$r9T$&$Y$-$@!"$H$N9M$($+$i!"$3$NL\E*$NMQ7o$rK~$?$9(BWHO-QOL-26$BI>2A%9%1!<%k$rMQ$$!"(B
$B<#NEA08e$NJQ2=$rD4::!&8!F$$7$F$_$?!JF|K\ElMN0e3X;(;o!"(B1999$B!((B49$B!Z(B6$B![(B180$B!K!#(B
$B!!$3$N(BWHO$B$NI>2A%9%1!<%k$H$O!"(BQOL$B$r0J2<$N#5NN0h#2#69`L\$KJ,N`$7$FI>2A$r9T$&$b$N$G$"$k(B-$B#1?HBNE*NN0h!J#79`L\!K#2?4M}E*NN0h!J#69`L\!K#3 $B!!BP>]$O!"F1%/%j%K%C%/e$K$o$?$C$F#5#0!s$N%3%s%W%i%$%"%s%9$r$b$C$F4AJ}Lt$rI~MQ$7$?#1#5Nc!#(B
$B45 $B!!$=$N7k2L!"<#NE8e$NJ?6QCM$O<#NEA0$HHf3S$7M-0U$J2~A1$rG'$a$?!J#p!c#0!%#0#1!K!#(B
$B$3$l$rNN0hJL$K$_$k$H!"#2?4M}E*NN0h$H#5A4BN$GM-0U$J2~A1!J#p!c#0!%#0#1!K!"#44D6-$G$b2~A1798~!J#p!c#0!%#1!K$,G'$a$i$l$F$$$k!#(B
$B-"$,$s45 $B!!!V4b:YK&$KBP$9$k=I~$9$k$3$H$K$h$C$F!"<#NE8z2L$r>7Mh$;$7$`$kLtJ*$^$?$O;n$_!W$HDj5A$5$l$F$$$k(BBRM$B!J(BBiological Response Modifiers)$B$,!"(B
$B6aG/CmL\$r=8$a$k$h$&$K$J$j!"F|K\(BBRM$B3X2q$bAH?%$5$l$F$$$k!#(B
$B!!$=$NBh#1#02s3X=Q=82qAm2q$K$*$$$F!"El;%KZIB1!4KOBFb2J$NC.8+MU;R;a$i$O!"(BBRM$B@=:^E*$J:nMQ$,4|BT$5$l$k4AJ}@=:^$r!"=*Kv4|4b45 $B?HBN>I>u$H(BQOL$B%9%3%"$*$h$SLH1V5!G=$rB,Dj$7$?7k2L$rJs9p$7$?!J(BBiotherapy,1998$B!((B12$B!L(B5$B!M(B820-822$B!K!#(B
$B!!BP>]$O?J9T4b45.:YK&4b$HF}4b$,3F#2?M!"GYBg:YK&4b$H0-@-A!0]@-AH?%5e0\$,$"$k!#(B
$B0JA0$N<#NE$O!"#5#4:P$NF}4b45#8?M$O2=3XNEK!$r $B!!$3$l$i452A$HLH1V5!G=$NB,Dj$r$7$?!#(B
QOL$B$NI>2A$O!"7*86HI$N(BQOL$B $BLH1V5!G=$O!"(BNK$B3h@-!"(BCD$B#3!J(B+$B!K!"(BCD8$B!J(B+$B!K!"(BCD4$B!J(B+$B!K(B/CD$B#8!J(B+$B!KHf!"(BCD20$B!"(BIL-$B#6$rB,Dj$7$?!#(B
$B!!EjM?$7$?4AJ}@=:^$H$=$N?M?t$O!"?M;2M\1IEr#5?M!"JdCf1W5$Er#3?M!" $B!!$=$N7k2L!"LH1V5!G=8!::$NM-0U$J2~A1$OG'$a$i$l$J$+$C$?$,!"<+3P>I>u$N2~A1$H7*86HI$N(BQOL$B%9%3%"$N2~A1$rG'$a!"!V4AJ}Lt$OM-MQ$J4b<#NEK!$G$"$k$3$H$,<(:6$5$l$?!W$H$7$F$$$k!#(B
$B!!$J$*$3$l$i$N4AJ}@=:^$K4X$9$k:nMQ5!=x$K$D$$$F$O!"$9$G$K$$$/$D$+$N8&5f$,$"$k!#(B
$B$?$H$($P7D1~5A=NBg3X0e3XIt>C2=4oFb2J$N6b;RJ8I';a$i$O!J>C2=4o4b$NH/@8$H?JE8!"#1#9#9#7!(#9!'#4#6#5!]#4#6#8!K!"(B
$BJdCf1W5$Er!"==A4BgJdEr!"?M;2M\1IEr$N%R%HG]M\4N4b:YK&$KBP$9$kD>@\$N93 $B$=$N7k2L!"@8BNKI8f5!G=$r2sI|$5$;$k0J30$K!"D>@\$K4b:YK&$NA}?#$rM^@)$7$F$$$k2DG=@-$,<(:6$5$l$?$H$7$F$$$k!#(B

$B-#LH1VG=$H(BQOL$B$N2~A1$r$_$?(BC$B7?4N9EJQ9gJ;Kv4|4N4b(B
$B!!?J9T$7$?Kv4|4N4b$G$,$s@-aVDK$r$-$?$9$h$&$J>l9g$O!"0lHL$K$O4KOBNEK!$H$7$F%b%k%R%M$GDCDK$r9T$$!"?);v$N@]uBV$N2~A1$r$O$+$k$?$aCf?4@EL.1IM\$,IU2C$5$l$k!#(B
$BKL3$F;8|@8O"L9@n8|@8IB1!$N0fc70NLp;a$O!"$3$N$h$&$J>uBV$N45 $BD94|1dL?8z2L$OF@$i$l$J$+$C$?$,!"LH1VG=$H(BQOL$B$N2~A1$r$_$?$H!XJL:}!&0e3X$N$"$f$_!!4N<@45$N4AJ}<#NE!Y!J#1#9#9#8!(#1#3#5!]#1#3#6!K$KJs9p$7$?!#(B
$B!!45 $B#8#6G/$+$i!"M"7l$K$h$k$H;W$o$l$k(BC$B7?4N9EJQ$G<#NE$r $B $B#9#5G/$K$J$jB?H/@-$G$"$k$3$H$,$o$+$j!"A4?H>uBV$J$I$,0-2=$7$?$?$a!"CO85$G$N<#NE$r4uK>$7Mh1!!#2HB2Nr$KFC5-$9$Y$-$3$H$O$J$7!#(B
$B!!=i?G;~$O!"A4?H7qBU46$r $B%F%,%U!<%k(B/$B%&%i%7%kG[9g:^$OCf;_$7!"30MhDL1!<#NE$G%D%`%iJdCf1W5$Er!J#7!%#5#g!?F|!K$rEjM?$7$?!#(B
$B!!$=$N8e!"A4?H>uBV$H?)M_$O2~A1798~$K$"$C$?$,!"#87n#7F|4b@-aVDK$GF~1!$7!"1v;@%b%k%R%M:BLt#1#0#m#g$r#8;~4V$4$H$KEjM?!#(B
$B4AJ}Lt$O7P8}@] $B#97n$+$i0BDj$7$?>uBV$,B3$-!"#1#17n2<=\$+$i30=P2DG=$H$J$j30Gq$b$7$?$,!"#1#27n2<=\$+$iuBV$N5^B.$J0-2=$,$"$j!"#9#6G/#17n#2#4F|4N9EJQ$H(BDIC$B$N$?$a1JL2$H$J$C$?!#(B
$B!!0fc7;a$O!VJdCf1W5$Er$NEjM?3+;O8e!"Kv>?7l%j%s%Q5e?t$*$h$S(BNK$B:YK&3h@-$,>e>:$7!"$=$l$KH<$C$F#Q#O#L$N2~A1$b$_$i$l$?$3$H$+$i!"(B
$BLH1VG=$N2~A1$,NW>2>I>u$N2~A1$K4sM?$7$?2DG=@-$,<(:6$5$l$?!W$H=R$Y$F$$$k!#(B

$B-$%$%s%?!<%U%'%m%s$H$NJ;MQ$G(BCR$B$rF@$??U:YK&4bGYE>0\Nc(B
$B!!3NN)$5$l$?M-8z$J<#NEK!$,$J$/M=8e$bITNI$J!"1s3VE>0\$rM-$9$k?U:YK&4b$N>INc$K$*$$$F!"(BBRM$B:^$G$"$k%$%s%?!<%U%'%m%s$H4AJ}Lt$rJ;MQ$7(BCR$B!J(Bcomplete response:$B40A4>C<:!K$rF@$?!"(B
$B$HIY;30e2JLt2JBg3XHgG"4o2J$NN$8+Dj?.;a$i$,Js9p$7$?!JHgG"4o302J!"#1#9#9#4!(#7!L#2!M#1#6#5!]#1#6#9!K!#(B
$B!!45o$J$7$H8@$o$lJ|CV!#(B
$B#9#0G/#1#07n7lab$G@V==;zIB1!Fb2J$r0\$H?GCG$5$l!"#9#0G/#1#07n#1#7F|Ev2J$K>R2p$5$l$?!#(B
$B!!?HD9#1#5#6#c#m!"BN=E#4#6!�#k#g!#?U(BCT$B$G:8?U>e6K$K7BLs(B6cm$B$N=<e6K$KCxL@$J7l4I?7@8A|$H(Btumor stain$B$rG'$a$?!#(B
$B!!#9#0G/#1#07n#2#5F|!":8?UF0L.:I@r=Q$r;\9T!#(B
$B#1#07n#3#0F|!"7PJ"KlE*:8?UE&=P=Q$r;\9T$7!"GYE>0\Ac$K#r(BIFN-?-2a 3$B!_(B10$B!!(B6$BC10L!"7W#1#82s6ZCm$r;\9T$9$k$,!"(BNC$B!J#n#o!!#c#h#a#n#g#e!'ITJQ!K$G$7$+$bI{:nMQ$,$"$jCf;_!#(B
$B#9#1G/#27n#1#8F|B`1!$H$J$j7P2a4Q;!$7$F$$$?$,!"#67n#3F|$h$j#r#I#F#N!>(B?$B#1!_#1#0!!#6C10L!"=5#22s@ECm$KJQ99$7!"(B
$B$5$i$K?)M_IT?6!&0WHhO+46$,;}B3$7$F$$$?$N$GEv1!OB4A?GNEIt$HAjCL$7!"JdCf1W5$Er#7!%#5#g(B/$BF|!JJ,#3!K$N7P8}EjM?$rJ;MQ$7$?!#(B
$B!!EjM?#1%u7n8e!"6;It#X@~8!::$G$OL@$i$+$J#c#o#i#n!!#l#e#s#i#o#n$O#2#0!_#1#8-P$N#18D$@$1$K$J$j!"$5$i$KEjM?#4%u7n8e$K$O!"E>0\Ac$O6;It#C#T$G$bG'$a$i$l$:!"#4=54V0J>e?7IBAc$N=P8=$b$J$$$N$G#C#R$HH=Dj$7$?!#(B
$B#9#1G/(B1$B#27n$K$OF~1!A0$NBN=E#4#6!%#5(Bkg$B$K$b$I$j!"#9#2G/(B1$B7n$+$i!"#r#I#F#N!>(B?$B#1!_#1#0!!#6C10L!"=5#12s@ECm$KJQ99$77QB3EjM?$7$F$$$k$,!"#3#0%u7n4V$K$o$?$j(BCR$B$r0];}$7$F$$$k!#(B
$B<+3P>I>u$G$O!"4AJ}LtEjM?(B1$B%u7n8e$h$jJ"DK$,>C<:!"#2%u7n8e$h$j?)M_IT?6$b>C<:$7$F$$$k!#(B
$B!!N$8+;a$i$O!VJdCf1W5$Er$O!"%$%s%?!<%U%'%m%s$NI{:nMQ7Z8:$K$bM-0U5A$JLt:^$H;W$o$l$?!W$H=R$Y!"$5$i$K!VK\>INc$G$O!"JdCf1W5$Er$K$h$jM6H/$5$l$?(BIFN-?$B$HDcMQNL#r#I#F#N(B?$B$H$,Aj>hE*$K:nMQ$7!"(B
$BM-8z$G$"$C$?$N$G$O$J$$$+$H9M$($i$l$k!W$H$7!"!V4AJ}Lt$,45Z$H$"$($P!"%$%s%?!<%U%'%m%s$H$NJ;MQNEK!$bM-8z$G$"$k$3$H$,<(:6$5$l$?!W$H9M;!$7$F$$$k!#(B

$B-%2=3XNEK!Cf;_$H$J$C$?0-@-%j%s%Q $B!!El5~Bg3X0e3XItBh0lFb2J$N1J0fNIMN0e3XE*<#NE$,.!&>C<:$7$?#1Nc$rJs9p(B
$B!J4AJ}$NNW>2!"#1#9#9#9!'#4#6(-#3(-#6#1#1!>#6#1#6!K$7!"4AJ}<#NE$KH?1~$7$&$kNc$b$"$k$3$H$r<($7$?!#(B
$B!!45 $B7W#82s!JF~1!Cf#22s!"B`1!8e30Mh$G#62s!K$N2=3XNEK!$r2<;h!JI($+$i2 $B!!=i?G;~$O!"?HD9#1#7#3-Q!"BN=E#6#3-T!"7l05#1#5#0!?#8#0-P#H#g!">e2<;h$N6ZNO$*$h$S?(3P!&DK3P$N0[>o$J$7!"1&3\27B#2!%#5-Q!"#1-Q!"1&B'ptIt$K#1!%#5!_#1-Q!":83\2 $B!!<#NE$O!" $B!!1j>I@-$N%j%s%Q@a.INcJs9p$"$j!K$K!"$5$i$K934b:nMQ$,4|BT$5$l$k@8Lt$+$o$i$?$1!J#8!%#0!K$r2C$($?!#(B
$B$3$N=hJ}$rEjM?$7$?$H$3$m!"#2=54V8e$K1&3\2.$7!"$5$i$K#2=54V8e$K$O$$$:$l$b?(CN$7$J$/$J$j!":83\2.$7$?!#(B
$B$=$N$?$a!"M=Dj$7$F$$$?2=3XNEK!$OCf;_$H$J$j!"$^$?8!::$N7k2L!"#L#D#HCM$b4AJ}<#NEA0Ls#6#0#0$,#3#7#4$^$G2<9_$7$F$$$?$H$$$&!#(B

$B-&>C2=4o4b=Q8e$N#Q#O#L2~A1(B
$B!!=Q8e$NBNNODc2<$dLH1V5!G=Dc2<$X$N4AJ}NEK!$NM-MQ@-$K$D$-!"?@F`@n8)N)$,$s%;%s%?!<$N2,K\t!=jD9$i$O!":G$b;HMQIQEY$N9b$$==A4BgJdEr$r2N>LL$+$i8!F$$7$?(B
$B!JF|K\>C2=4o302J3X2q;(;o!"#1#9#9#5!'#2#8(-#4(-#9#7#1!>#9#7#5!K!#(B
$B!!$=$N%^%&%9$K$h$k/$NAK;_!"#N#K:YK&3h@-Dc2<$N7Z8:$rG'$a$?!#(B
$B!!NW>2E*$K$O!"%"%s%1!<%H7A<0$G#Q#O#L$rD4::$7!"$=$N;~E@$G$N@82=3XE*!&LH1V3XE*$J8!::$HHf3S8!F$$7$?!#BP>]$O(B109$BNc!JCK#5#5Nc!&=w#5#4Nc!K!#(B
$B<@45$NFbLu$O!"0_4b#3#1Nc!&7kD24b#4#0Nc!&D>D24b#2#6Nc!&F}4b#7Nc!&GY4b#5Nc$G!">C2=4o7O$N4b$N=Q8e$,$[$H$s$I$G$"$C$?!#(B
$B4AJ}Lt$O!"==A4BgJdEr$,D94|EjM?$5$l!"$[$+$K=aD2Er!&JdCf1W5$Er$b;HMQ$5$l$?!#(B
$B!!=Q8e$N#Q#O#L$O!"?HBNE*>u67$K$D$$$F$O#9#0!s0J>e!"@:?@E*>u67$K$D$$$F$O#8#5!s0J>e$,K~B-$7$F$$$k$H2sEz$7$?!#(B
$B0WHhO+@-$O=Q8e$K:G$bA}Bg$7$?=%AJ!JLs#6#0!s!K$G$"$k$,!"LH1V3XE*$K$O#N#K:YK&$H$NAj4X$,G'$a$i$l$?!#(B

$B-'0_@Z=|8e$NJ-9gIt69:u$K$h$k>C2=4o>I>u$N>C<:(B
$B!!0_@Z=|8e$K$7$P$7$P=P8=$9$k!"$D$+$(46!&SR5$!&$b$?$l!&>eJ"ItKDK~46$J$I$N!"J-9gIt69:u$K$h$k>C2=4o>I>u$O!"@>MN0e3XE*<#NE$G$OFq$7$$$b$N$,B?$$!#(B
$B7D1~5A=NBg3XIB1!4AJ}%/%j%K%C%/$NJ!_7AG;R;a$i$O!"$3$l$i$N>INc$K$O!"=QD>8eNc$HD94|7P2aNc$N$$$:$l$K$b4AJ}<#NE$,BgJQM-8z$G$"$k$H=R$Y$F$$$k(B
$B!JF|K\ElMN0e3X;(;o!"(B1999$B!((B49$B!L(B6$B!M(B155$B!K!#(B
$B!!>INc#1$O!"(B59$B:P!"CK@-!#0_4b$G0_$r@Z=|!J#B(B-$B#IK!!K$7$?$,!"#1#5F|L\$KJ-9gItIb $B4AJ}Lt$Nh*Nj0{$rEjM?$7$?$H$3$m!"MbF|$K$O>I>u$N2~A1$r$_$?!##2F|8e$K0_Fb;k6@8!::$GJ-9gItIb $B!!>INc#2$O!"#6#8:P!"CK@-!#Aa4|0_4b!J-6#c!K$G0_$r@Z=|!J#B(B-$B#IK!!K$7!"#1#1F|8e$KJ-9gIt69:u$K$h$k$D$+$(46!&0_4b$,8=$l$?!#(B
$BB`1!8e#1G/4V302J$G<#NE$rI>u$O$[$H$s$I>C<:$7$?!#(B
$B!!>INc#3$O!"#6#4:P!"CK@-!#0_DYag$G0_$r@Z=|!J#B(B-$B#IK!!K$7$?$,!"$=$N8eLs#5G/4V!"$D$+$(46!&$b$?$l!&>eJ"ItKDK~46$J$I$,B3$-!"302J$G<#NE$r $Bh*Nj0{$rEjM?$7$?$H$3$m!"Ls#2=54V$G>eJ"ItKDK~46$,>C<:!"#1%u7n8e$K$O>I>u$,$[$H$s$I>C<:$7$?!#(B

$B-(#C#r#o#h#nIB45e(B
$B!!8=:_#C#r#o#h#nIB$O860xITL@$N$?$a!"<#NE$G$O#Q#O#L$N8~>e$,$=$NL\E*$H$J$k!#(B
$BD94|7P2aCf$K$7$P$7$P%$%l%&%9$,@8$8$F!" $B$3$l$KBP$7$F$O4AJ}Lt$,M-MQ$J<#NE$N0l$D$G$"$k!"$HEl5~$N $B!!BP>]$O#5#3Nc!JCK#4#2Nc!&=w#1#1Nc!K!"G/Np#1#6!A(B53$B:P!JJ?6Q#3#3!:P!K$$$:$l$bF11!#C#r#o#h#nIB30Mh$KDL1!<#NECf$G!"IBJQItD24I69>.2=$rDh$7!"(B
$B:_Bp@.J,7P4I1IM\!J#1F|(B600$B!A(B900$B#k#c#a#l!K$r9T$C$F$$$k!#IB7?$O>.D27?(B28$BNc!&>.D2BgD27?(B25$BNc$G!"D24I@Z=|$"$j#3#2Nc!&$J$7(B21$BNc!"8}B&D24I3HD%$"$j#1#9Nc!&$J$7#3#4Nc!#(B
$B!!F11!$G$OD24I69:u>.2=$rG'$a$?45I$rM=B,$7!":_Bp$G45 $BMh1!;~$NJ"ItC1=c $B!!:#2s$N45uBV$rHf3SBP>H$H$7$?!#(B
$B!!$=$N7k2L$r8}B&D24I3HD%$NM-L5$GJ,$1$F$_$k$H!"3HD%$rH<$&Nc$G$OBg7zCfErEjM?$K$h$j%$%l%&%9$r2r=|$7F@$?$N$O#1#9NcCf#9Nc!J;~4V#4!A#4#8;~4V!K$G!"#1#3Nc$,F~1!$NE>5!$r$H$C$F$$$k!#(B
$B$7$+$7!"3HD%$rH<$o$J$$Nc$G$O!"A4#3#4Nc$,30Mh<#NE$G#1#2;~4V0JFb!JJ?6Q#5!#6!^(B2$B!&(B10$B;~4V!K$K%$%l%&%9$,>C<:$7$F!"F~1!$NI,MW$O$J$+$C$?!#(B
$B$J$*3HD%$rH<$o$J$$Nc$G$NHsEjM?;~$N%$%l%&%92r=|;~4V$OJ?6Q#8#4!#2!^#3#0!�#2;~4V$G!"$3$l$HHf3S$9$k$HMQES;~$N$[$&$,M-0U$KC;=L$7$F$$$k!J#p!c#0!%#0#0#1!K!#(B
$B9bE:;a$O!V#Q#O#L$N8~>e$K;q$9$k$3$H?S$@$7$/M-MQ$G$"$k$H;W$o$l$k!W$H=R$Y$F$$$k!#(B

$B-)=Q8e%$%l%&%9<#NE$KBP$9$kM-MQ@-(B
$B!!Bg7zCfEr$K$D$$$F$O!"El5~;|7C0e2JBg3XBh#2302J$N8E@nNI9,;a$i$,!">C2=4I1?F0$KBP$9$k:nMQ$H=Q8e%$%l%&%9<#NE$KBP$9$kM-MQ@-$r8!F$$7!"Js9p$7$F$$$k(B
$B!JF|K\>C2=4o302J3X2q;o!"(B1995$B!((B28$B!L(B4$B!M(B956-960$B!K!#(B
$B!!%$%L$K$h$k4pACC2=4I1?F0$KBP$9$k:nMQ$,!"=i$a$F2J3XE*$K>ZL@$5$l$?!#(B
$B$9$J$o$A!"Bg7zCfErEjM?8e$K0_!"==Fs;XD2!"6uD2!"2sD2$N1?F0P6?J$,4Q;!$5$l!"0_G4KlKc?l8e$G$O!"$3$l$i$N1?F0P6?J:nMQ$OA4$/G'$a$i$l$J$+$C$?!#(B
$B!!NW>2E*8!F$$G$O!"%$%l%&%9$GF~1!$7$?#9#3Nc$rBP>]$K$7$?!#$&$A $BJ]B8E*<#NE#6#9Nc!JBg7zCfErEjM?#2#0Nc!&HsEjM?#4#9Nc!K$G!"$$$:$l$b>INc$NGX7J$KJP$j$O$J$$!#(B
$BM-0U:9$rG'$a$?$N$O:_1!F|?t$G!"EjM?72#2#1!%#8!^#2!%#4F|$KBP$7$FHsEjM?72#2#7!%#7!^#2!%#9F|$G$"$C$?!#(B
$B!!8E@n;a$i$O!"!V%$%L$K$h$kF0J*l9g!":GBg8z2LH/8=;~4V$^$G$K$OLs#3#0J,$+$+$j!"(B
$BEjM?8e$3$N4|4V$O%$%l%&%94I$r2rJ|$9$Y$-$G$O$J$$$b$N$H9M$($i$l$?!W$H$7!"$5$i$K!V%$%l%&%9$KBP$9$kBg7zCfErNEK!$O!"(B
$B302J0e$,4|BT$9$k0J>e$KM-8z$G$"$k>l9g$,B?$/!"45 $B!!$J$*F1$8302JNN0h$G!"2#IM;TN)Bg3X0e3XIt5_L?5_5^%;%s%?!<$N?y;39W=u65 $BB?;\@_6&F18&5f$7$F$$$k!J#P#r#o#g#r#e#s#s!!#i#n!!#M#e#d#i#c#i#n#e!$(B1993$B!((B13$B!'(B2901-2907$B!K!#(B
$B$=$7$F!"2A$G$d$dM-MQ0J>e$,#6#1NcCf#8#8!%#5!s$H!"NI9%$J@.@S$,F@$i$l$?$H$7$F$$$k!#(B

$B-*9bNp $B!!BeI=E*$JJd:^!JLH1VNO!"B$7l5!G=!">C2=5!G=$J$I$r0z$-=P$73h@-2=$9$k:nMQ$r$b$DLt:^!K$G$"$kJdCf1W5$Er$,!"(B
$B2CNp$KH<$C$FDc2<$9$k?4?H$N=t5!G=$N2~A1$KM-MQ$+$I$&$+$r8!F$$7$?Js9p$,!"Bh#4#92sF|K\ElMN0e3X2q3X=QAm2q$G!"(B
$B0&I2Bg3X0e3XIt0e2J3XBh#2$NFs5\M59,;a$i$K$h$C$F9T$o$l$?!JF|K\ElMN0e3X;(;o!"#1#9#9#8!'#4#8(-#6(-#1#5#5!#(B
$B!!BP>]$OO77r;\@_$NF~1!45H72$H$7$FBg\'!J%J%D%a!K#3#gC1FHEjM?72$K$o$1!"(B
$B$=$l$>$l#4=54VEjM?$7!"$=$NA08e$K7l1U@82=3X8!::!"@:?@?@7P3XE*8!::!"<+3P>I>u$*$h$S#A#D#L2~A18e$N%"%s%1!<%H$J$I$r9T$$8!F$$7$?!#(B
$B!!#4=54VEjM?40N;$7$?$N$O!"JdCf1W5$Er72#8L>!JCK#1L>!&=w#7L>!"J?6QG/Np#8#4!%#1:P!K!"BP>H72#8L>!JCK#3L>!&=w#5L>!"J?6QG/Np#8#3!%#5:P!K$G$"$C$?!#(B
$B!!NW>28!::7k2L$G$O!"EjM?A08e$KM-0U$JJQ2=$O<($5$l$F$$$J$$$,!"F|>o@83hF0:n!J#A#D#L!K$NI>2A$H$7$F$N#B#a#r#t#h#e#l!!#I#n#d#e#x$NJQ2=$,2~A1$r<($7$?!#(B
$B$3$l$O!"!VF|>o@83h$K2p8n$NDxEY$,7Z$/$J$j!"<+N)$7$F$b$N$4$H$r9T$&$h$&$K$J$k798~$r<($7$F$$$k!W!#$J$*$$$:$l$N72$G$b4N>c32$d?U>c32$NH/>I$O$J$/!"I{:nMQ$bG'$a$i$l$J$+$C$?!#(B

$B-+NEM\7?IB>272$K$*$1$k8z2L(B
$B!!NEM\7?IB>272$H$O!"K}@-4|0eNE$NDj3[2J$NJ}?K$K$h$j!"0lIt8xE*2p8nJ]81$K8~$1$FF3F~$5$l$?IBAc72$G!"(B
$B0lHLIB1!$KHf$Y45/$J$$$+$o$j$K!"IB>2LL@Q$,9-$/!"2p8n%9%?%C%U$d?)F2!&CLOC< $B457l4I>c328e0d>I$G!"$[$\@>MN0e3XE*$J<#NE$O40N;$7!"$"$^$jM-8z$J<#NE$,$J$$$H$$$&LdBj$r$+$+$($F$$$k!#(B
$B!!0eNEK!?MTh@82q!&2$NNEM\7?IBAc72$K$*$$$F!"@>MN0e3X$N$_$r3X$s$G$-$?0e;U#4?M$K#1G/4V4AJ}0e3X$r65$($J$,$i!"(B
$B4AJ}<#NE$r<+M3$K9T$C$F$b$i$C$?7k2L$r8!F$$7$F$$$k!J0eNE7P1D>pJs!"#1#9#9#9!(#N#o!%(B113$B!'(B16-18$B!K!#(B
$B!!$=$N7k2L!":G$b82Cx$JF0$-$O!"45/$G$"$C$?!#(B
$B@>MNLt$N$_;HMQ$NJ?@.#9G/EY>eH>4|$,#1F|#1?MEv$?$j#1#3#9#41_$G$"$C$?$N$KHf$Y!"4AJ}Lt$rJ;MQ$7$?J?@.#1#0G/EY>eH>4|$OF1$8$/#7#4#11_!J$&$A4AJ}Lt$O#1#1#71_!K$G!"(B
$B8:$jJ}$bJP$C$?$b$N$G$J$/B?4t$K$o$?$k$b$N$G$"$C$?!#35;;$9$k$H#2#0#0>2$NIB1!$G!"G/4V#4#7#6#7K|1_$N@a8:$K$J$k!#L5M}$KCf;_$7$?$b$N$G$O$J$/!"<+$:$H8:$C$F$$$C$?$b$N$@$H$$$&!#(B
$B!!;HMQ$7$?4AJ}Lt$O!">e$+$i=g$KEv5"giLt;6!"?M;2M\1IEr!"==A4BgJdEr!"H,L#4]!"M^4N;62CDDHiH>2F!"Kc;R?N4]!"JdCf1W5$Er!" $BM-L>$J=hJ}$,$[$H$s$I$G$"$k!#$7$+$7$"$kDxEY$NJY6/$OI,MW$G!"KhF|>/$7$:$D4AJ}$N652J=q$rNXFI$7$?@.2L$G$"$m$&$H$7$F$$$k!#(B
$B!!45e$2$i$l$F$$$k!#(B
$B#1!%Bh;0!"Bh;M@$Be$N93@8:^$,BgI}$K8:>/$7!"$5$i$KBh0l!"Bh;M@$Be$N$b$N$^$GH>8:$7$F$$$k$3$H$+$i!"(B
$B0W46@w@-$K$D$$$FM-8z$G$"$C$?$3$H!JB>1!$+#rE>1!;~$K$9$G$K;}$C$F$$$?#M#R#S#A$,!"4AJ}Lt$G>C<:$7$?Nc$b$"$j!K!#(B
$B#2!%@:?@IT0B$d0U<1Dc2<$J$I$N@:?@>I>u$KBgJQM-8z$G!"WQWK$7$?$jK=$l$?$j$9$k$3$H$,>/$J$/$J$C$?$3$H!#(B
$B#3!%?)M_IT?6$,CxL@$K2~A1$9$kNc$,B?$/!"E@E)$,>/$J$/$J$j!"%9%?%C%U$N;~4V$N@aLs$K$b$J$C$?$3$H!#(B

$B-,0UM_Dc2<7?G>7l4I@-CTJr$KBP$9$k8z2L(B
$B!!C^GHIB1!$N66K\5~;R;a$i$HEl5~=w;R0eBg?@7P@:?@2J$N8&5f%0%k!<%W$,!"O7G/4|CTJr$N$&$A0UM_Dc2<7?$NG>7l4I@-CTJr45 $B7K;^2CN59|24iZEr$rEjM?$7$?7k2L$r!"!XF|K\ElMN0e3X;(;o!Y!J#1#9#9#8!(#4#8!L(B6$B!M(B155$B!K$KJs9p$7$F$$$k!#(B
$B!!BP>H$O!"C^GHIB1!F~1!Cf$N#6#0:P0J>e$N45!&=w#7L>!#A40w$,D9C+@n<0CTJr%9%1!<%k#5E@L$K~$N=EEYCTJr$G!"0UM_Dc2<7?$NG>7l4I@-CTJr45 $B4AJ}Lt$O#7!%#5#g$r#1F|#32s!"#6=54VEjM?$5$l!"@:?@>I>u$HElMN0e3XE*?HBN=j8+!J@e!&L.!&J"It$J$I!K$K$D$$$F7P;~E*$JJQ2=$r8!F$$7!"$3$l$iN>LL$+$i8z2L$rH=Dj$7$?!#(B
$B!!7k2L$O!"#1L>$,9gJ;>I$G;`K4$7$?$N$G;D$j#1#1L>$G8!F$$7$?!#D9C+@n<0CTJr%9%1!<%k$N2~A1Nc$O$J$+$C$?$,!"A4HL2~A1EY$G$OCxL@2~A1#3Nc!&CfESEY2~A1#5Nc!&7ZEY2~A1#2Nc!&ITJQ#1Nc!&0-2=#0Nc$G$"$C$?!#(B
$B$^$?ItJ,>I>uJL8z2L$G$O!"H/F0@-!"IT0B!&?45$>I>u!"H/8l!"G'CN>c32$K$*$$$FM-0U$J8z2L$,G'$a$i$l$?!#?HBN=j8+$G$O!"EjM?A0$KJ"D>6Za[5^$r<($7$?#7NcCf#6Nc$,!"EjM?8e$KCxL@2~A1$r<($7$?!#(B
$B!!K\66;a$i$O!"!VA4HL2~A1EY$O!"7ZEY2~A10J>e$N8z2L$,#8#0!s0J>e$H8zN($G$"$j!":#8eM-8z$J<#NEK!$N0l$D$H9M$($i$l$?!W$HAm3g$7$F$$$k!#(B

$B--?2$?$-$jO7?M$N#A#D#L$rCxL@$K2~A1(B
$B!!%j%O%S%j%F!<%7%g%so@83hF0:n!J#A#O#L!K$,2~A1$G$-$?!"(B
$B$H%j%P!<%5%$%I%[%9%T%?%kElMN0e3X%;%s%?! $B!JF|K\ElMN0e3X;(;o!"#1#9#9#6!'#4#7(-#2(-#2#5#3!>#2#6#0!K!#?2$?$-$jO7?M$KBP$9$k!"4AJ}0e3X$N4sM?$r6qBNE*$K<($9Nc$H$7$FCmL\$5$l$k!K!#(B
$B!!Js9p$O#2>INc$G!">INc#1$O#7#6:P!"=w@-!##9#3G/#87n$/$bKl2<=P7l!JA08rDLF0L.$NF0L.an$K$h$k!K$GE]$l!"(B
$B%/%j%C%T%s%0$,9T$o$l$?!#Ls#5%u7n4V$NF~1!$G?2$?$-$j>uBV$H$J$j!"%j%O%S%j%F!<%7%g%s$H#A#D#L$N2~A1$rL\E*$K!"#9#4G/#47nF1%;%s%?!<$KF~1!!#(B
$B!!F~1!;~$O?HD9#1#5#6-Q!"BN=E#4#2-T!"7l05#1#4#0!?#7#0-P#H#g!"L.Go#8#0!?J,@0!"N>2<;h$K7ZEY$NKcac!"CxL@$JGQMQ@-0`=L!"0UM_$NDc2<$,$"$j!"(B
$B4pK\F0:n$OA42p=u>uBV!#7l1U8!::$G9b%3%l%9%F%m!<%k7l>I$rG'$a$?$[$+!"0[>o=j8+$O$J$7!#(B
$B!!Ls#2%u7n4V!"O;7/;REr%(%-%9$H%j%O%S%j%F!<%7%g%s$r9T$&!J8e$N#1%u7n$[$I$O?M;2Er%(%-%9J;MQ!K$,!"$[$H$s$I?2$?$-$j>uBV$G!"%j%O%S%j$X$N0UM_$b$J$7!#(B
$B#67n$+$iJ"It$N4AJ}E*=j8+$r=E;k$7!">.7zCfEr$KJQ99$7$?!##1#0J,DxEY$N:B0LJ];}$H!"2p=u$K$h$kN)0L2DG=$H$J$k$,!"%j%O%S%j$X$N0UM_$OIT==J,!#(B
$B$=$3$G#1#07n=i=\!">.7zCfEr$h$j$b5uO+%?%$%W$KMQ$$$k2+fM7zCfEr!J>.7zCfEr!\2+fM#1#0#g!K$rEjM?$7$?$H$3$m!"(B
$B#2=54VL\:"$h$j=y!9$K0UM_$N>e>:$,F@$i$l!"#A#D#L$,2~A1$7!"?H$N2s$j$N$3$H$,<+J,$G$G$-$k$h$&$K$J$j!"#9#5G/#77nB`1!$H$J$C$?!#(B

$BB3$/!"(B

$B!!(B$B!!(B$B!!(B