BIOCHEMISTRY & MOLECULAR BIOLOGY
HIGHER NERVOUS SYSTEM
KAMPO MEDICINE

Dr. HIROYUKI OHYAMA.(Ph.D)



Age-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori

Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan

                            
 



Age-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori

Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan

Dr. HIROYUKI OHYAMA(Ph.D) in 1995.





岡山大学 医学博士 分子細胞医学
徳島大学 薬学修士 生物薬品化学
大山博行(おおやまひろゆき)

1991
" THE KAMPO "



" KAMPO 漢方 "
How the Japanese Updated Traditional Herbal Medicine
Akira Tsumura, the Author 

About the Author :
Akira Tsumura has unique qualifications to brief us in the Western world
on the history and benefits of Japanese herbal medicine.
The pharmaceutical firm he heads has a long family tradition.
Tsumura, Inc. was founded by his grandfather, Jusha Tsumura,
and has diversified to become the leading supplier of herbal medicinals.
Sub-sidiaries in the United States are well-known distributors
of health and beauty care products.

At Tsumura, Inc. scientists using the latest technology
are testing the properties of various ancient Kampo medication.
In the Tokyo suburb of Tsuchiura, the firm has constructed a modern,
high-tech factory using robots for difficult research procedures.

The auther also has a warm appreciation of the needs
and attitudes of the American people.
His interest in Western culture has remained strong since he pursued a degree
in business management at the University of Michigan in Ann Arbor.
He has formed his own Dixieland jazz group in Japan, the Storyville Dandies !!!
His collection of vintage banjoes is the best in the world. 

" THE KAMPO "
1991

  


資料提供
大山漢方堂薬局





KAMPO MEDICINE
Tradition Guiding Innovation



Report of the 100th Anniversary International
Kampo Symposium '93 Tokyo, Japan
9-10 April 1993



Medicines of Plant Origin
Patient Benefit and
Japanese Kampo Therapy 1991

      

Program and Book of Abstracts

Report of an International Scientific
Workshop held in Bergen, Norway
31 May 1991

 


Recent Advances in the Pharmacology of
KAMPO MEDICINES
(JAPANESE HERBAL MEDICINES)
Proceedings of the Satellite Meeting on Kampo(Japanese Herbal) Medicines
of the 10th International Congress of Pharmacology,
Auckland, New Zealand, August 19-21, 1987

   

Basic and Clinical Studies of TJ-23 on Alzheimer's Dementia
Brain Research Conference for Japanese Kampo Medicine
1990

          





資料提供
大山漢方堂薬局


The First International Conference on Senescence: The SAM Model
March 17-18,1994 Kyoto, Japon
PROCEEDINGS OF THE FIRST SAM KYOTO SYMPOSIUM

 

THE COUNCIL FOR SAM RESEARCH
Dept.of pathology chest disease res.inst.,
Kyoto university,Japan.1988


          


This Issue Devoted to
Proceedings of the 18th Collegium Internationale
Neuro-Psychopharmacologicum Congress
Clinical Neuropharmacology

   

Collegium Internationale Neuro-Psychopharmacologium
18th C.I.N.P. CONGRESS
ACROPOLIS Convention Center,
Nice, France
June 28 - July 2, 1992


      



資料提供
大山漢方堂薬局



 

Medicines of Plant Origin in Modern Therapy
from the 4th World Conference on Clinical Pharmacology, Prague 1989



A SYMPOSIUM REPORT
Published by Oxford Clinical Communications,
1989




  

The English Guide to Medicinal Plants
and Kampo Formulae
1993

   

HERBAL MEDICINE : KAMPO,
Past and Present
1985


資料提供
大山漢方堂薬局


 


EUROPEAN JOURNAL OF PHARMACOLOGY
11th International Congress of Pharmacology
Amsterdam, The Netherlands
1-6 July, 1990




          


Free Radicals in Brain Physiology and Disorders
An International Conference
Held in Celebration of the Retirement of Professor Akitane Mori

    

August 4 and 5, 1995
International Convention Center PAMIR,
Tokyo,Japan

    


資料提供
大山漢方堂薬局









「脳を守る漢方薬」
脳の老化とボケの関係をわかりやすく解説
認知症(痴呆症)、アルツハイマー病に対する最新情報満載
誰にでもできるボケ予防の6ヶ条を紹介



著者
医学博士 大山博行
Dr.HIROYUKI OHYAMA(Ph.D)
研究業績





漢方を現代病に活かす!大山漢方堂薬局
鍼灸を現代病に活かす!医学博士 大山博行
医学博士 大山博行
Dr.HIROYUKI OHYAMA(Ph.D)



大山宗伯東洋医学記念館



' sohhaku OHYAMA ' memorial
Institute of Natural Health Science

大山宗伯東洋医学記念館





Image of Ohyama Kampo

" KEIRAKU."




Image of Ohyama Shimkyu






Image of Ohyama Kampo




sohhaku OHYAMA memorial
Oriental Medicine
(Kampo medicines, Acupuncture & Moxibustion)
Museum



Grandfather's Clock.



「1006」



「NAMBU]



「GOTOKU」



「YAKUKAN, YAKUTUBO & GOTOKU」



「balance」
昭和初期 上皿天秤
(分銅、ピンセット、木製ケース付)

 

「Medicine Cases」
江戸時代
漢方医の薬箱(革蓋付)



「Medicine Cabinets」
江戸時代
御殿医の薬味箪笥

the edo period
TONOSAMA / DAIMYOH / HATAMOTO



「Medicine Cases」
江戸時代
御殿医の薬箱(燭台、銅製薬缶付)

   

「Medicine Cabinets」

「Haribako」



Acupuncture & Moxibustion Box



Acupuncture & Moxibustion Box

「Kyubako」



「SAMURAI」

the edo period



「ATSUHIME」



「YAKUMI-TANSU」



「KUSURI-KANBAN #1」



Image of Ohyama Kampo

JAPANESE HERBAL MEDICINES



KAMPO MEDICINES



JAPANESE HERBAL MEDICINES



KAMPO MEDICINES

MEDICINE BOX

 

「Herbal Medicine Bag」



「KUSURI-KANBAN #2」



「KUSURI-KANBAN #3」


THE SAMURAI
EDO PERIOD
KUSURI-KANBAN

Image of Ohyama Kampo



          



Reference

BIOCHEMISTRY & MOLECULAR BIOLOGY

American Society for Biochemistry and Molecular Biology

A.S.B.M.B


      









DR.HIROYUKI OHYAMA(Ph.D)

1)

Age-related difference in synaptosomal membrane fluidity

Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori

Biochemistry and Molecular Biology International 37,133-140,1995

Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical

School, 2-5-1 Shikatacho, Okayama 700, Japan and *Division of Medical Science, Institute for Life

Support Technology, Yamagata Technopolis Foundation, Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan


2)

Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice

Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori

Magnetic Resonance in Medicine 6, 279-281, 1995


3)

Effect of Japanese herbal medicine(TJ-960), on aging

Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori

Lipid-Soluble Antioxidants:Biochemistry and Clinical Applications.

pp.535-552,Birkhauser Verlag,Basel,1992


4)

Combined treatment of Japanese herbal medicine(TJ-960)with low dose of dipropylacetate increased the latent time for

pentylenetetrazol induced convulsion and decreased brain lipid peroxidation in mice.

Hiramatsu,M., Liu J, Edamatsu,R., Kadowaki,D., Hamada,H., Ohyama,H., Watanabe,S., Mori,A.

Neuroscience 18, 71-76,1992


5)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain

Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.

in: The SAM Model of Senescence (T.Takeda, ed.) pp.343-346,Elsevier Science B.V., Amsterdam, 1994


6)

Age-related changes in nitric oxide content and nitric oxide synthase activity

in senescence-accelerated mouse (SAM P8) brain

Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.

in: Oxidative Stress and Aging (R.G.Cutler, L.Packer, J.Bertram, A.Mori, eds.)

pp387-391, Birkhauser Verlag, Basel, 1995


7)

UNESCO / Costam Workshop on Lipid-soluble Antioxidants in Biochemistry of Nutrition and Environmental Health

1991.9.21 (Malaysia)

Effect of Japanese herbal medicine(TJ-960), on aging

Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori


8)

Society for Free Radical Research 1991.9027 (Paris)

Japanese herbal medicine(TJ-960) affected free radicals, SOD activity,

lipid peroxidation and neurotransmitter in aged rat brain

Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori


9)

5th International Congress on Oxygen Radicals 1991.11.18 (Kyoto)

Decreased membrane fluidity in rat synaptosomes induced by active oxygen species,

guanidino compounds and convulsants

Midori Hiramatsu, Rei Edamatsu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori


10)

5th International Congress on Oxygen Radicals 1991.11.20 (Kyoto)

Antioxidant effects of the extracts of gastrodia fleta bl. and uncaria rhynchophylla (MJQ) jacks

Jiankang Liu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori.


11)

The First International Conference on Senescence: The SAM Model 1994.3.17 (Kyoto)

Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain

Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.


12)

The First International Conference on Oxidative Stress and Aging 1994.3.25 (Hawaii)

Age-associated changes in nitric oxide (NO) content and nitric oxide synthase (NOS) activity

in senescence accelerated mouse (SAM P8) brain

Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.


13)

International Conference on Bioradicals Detected by ESR Spectroscopy 1994.6.13 (Yamagata)

Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice

Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori


14)

International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects (ISNA) 1995.6.21 (Beijin)

Antioxidant defenses of Japanese herbal medicine(TJ-960) , against free radical induced neural cell damages

Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara


Reference

1)

Mixed Japanese Herbs and Age-Related Neuronal Functions

Midori Hiramatsu and Makiko Komatsu

Antioxidant Food Supplements in Human Health,edited by Lester Packer,

Midori Hiramatsu,Toshikazu Yoshikawa,pp.412-428,1999

2)

Effects of Japanese herbal medicine(TJ-960), on neuronal membrane fluidity of mice

Hiroyuki Ohyama,Midori Hiramatsu,Rei Edamatsu,Akitane Mori.

Magnetic Resonance in Medicine 6,279-281,1995

3)

Antioxidant effect of TJ-960, a Japanese herbal medicine, against free radical-induced neuronal cell damage

Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara

International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects(ISNA),pp.45-53.1996

4)

Effect of TJ-960 on generalized seizure in amygdaloid kindled cats

Susumu Iizuka, Atsushi Ishige, Kyoji Sekiguchi, Akira Sugimoto, Kouichi Itoh, Masaki Aburada, Eikichi Hosoya, Eiichi Sugaya

Recent Advances in the Pharmacology of Kampo Medicines pp.62-68,1988

5)

Normalizing effect of SK commercial formula on cytochalasin-B distorted neurites using primary cultured neurons of rat cerebeal cortex

Aiko Sugaya, Mitsutoshi Yuzurihara, Tadashi Tsuda, Eiichi Sugaya

J. Ethnopharmacol., 21: 193-199,1987.

6)

Effect of Kampo Medicine Preparations Using the Pathological Model of Dementia

Michihiro Fujiwara

Brain Research Conference for Japanese Kampo Medicine pp.67-81,1990

7)

Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain

Habu,H.,Yokoi,I.,Kabuto,H.,Ohyama,H.,Mori,A.,Teraoka,H.,Komaru,N.

The SAM Model of Senescence(T.Takeda,ed.) pp.343-346,

Elsevier Science  B.V.,Amsterdam,1994

8)

Mixed Natural Antioxidants

Hiramatsu,M.

Food and Free Radicals,edited by Hiramatsu et al.

Plenum Press,New York,pp.113-117,1997



DR.HIROYUKI OHYAMA(Ph.D)


BIOCHEMISTRY & MOLECULAR BIOLOGY
HIGHER NERVOUS SYSTEM
KAMPO MEDICINE



Dr. HIROYUKI OHYAMA.(Ph.D)
1999

      

BIOCHEMISTRY & MOLECULAR BIOLOGY

          






References 1

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(2) Price D.L., Whitehouse P.J. and Struble R.G. Alzheimer's diseases. Ann. Rev. Med. 36, 349-356, 1985.

(3) Appleyard M.E., Smith A.D., Wilcock G.K and Esiri M.M. Decreased CSF acetylcholinesterase activity in Alzheimer's disease. Lancet 20, 452, 1983

(4) Lovell M.A., Ehmann W.D., Butler S.M. and Markesbery W.R. Elevated thiobarbituric acid reactive substances and antioxident enzyme activity
in the brain in Alzheimer's disease. Neurology 45, 1594-1601, 1995.

(5)Mutisya E.M., Bowling A.B. and Beal M.F. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63, 2179-2184, 1994.

(6) Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F. and Floud R.A. A model for α-amyloid aggregation and neurotoxicity based
on free radical generation by the peptide: Relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 3270-3274, 1994.

(7) Kasai H. and Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12, 2137-2145, 1984.

(8) Shibutani S., Takeshita M. and Grollman A.P. Insertion of specific nases during DNA synthesis past the oxidation damage base 8-oxodG. Nature 349, 431-434, 1991.

(9) Cheng K.C., Cahill D.S., Kasai H., Nishimura S. and Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage,
causes G→T and A→C substitutions. J. Biol. Chem. 267, 166-172, 1992.

(10) Prasad G.S., Lovell M.A. and Markesbery W.R. Increased nuclear DNA oxidation in the brain in Alzheimer's diseases. J. Neurochem. 71, 2034-2040, 1998.

(11) Sohal R.S., Agarwal S. and Sohal B.H. Oxidative stress and aging in the Mongolian gerbil (Meriones unquiculatus). Mech. Ageing and Dev. 81, 15-25, 1995.

(12) Asuncion J.G., Millan A., Pla R., Bruseghini L, Esteras A., Pallardo F.V., Sastre J. and Vina J. Mitochondrial glutathione oxidation correlates
with age-associated oxidative damage to mitochondrial DNA. FASEB J. 10, 333-338, 1996.

(13) Sastre J., Millan A., Asuncion J.G., Pla R., Juan G., Pallardo F., O'Conner E., Martin J.A., Droy-Refaix M.T. and Vina J. A Ginkgo biloba extract (EGb 761)
prevents mitochondrial aging by protecting against oxidative stress. Free Rad. Biol. Med. 24, 298-304, 1998.

(14) Mecocci P., Fano G., Fulle S., MacGarvey U., Shinobu L., Polidori M.C., Cherubini A., Vecchiet J., Senin U. and Beal M.F. Age-dependent increases
in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Rad. Biol. Med. 26, 303-308, 1999.

(15) Ciani E., Groneng L., Voltattorni M., et al. Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated
by glutamate in cultures of cerebellar granule neurons., Brain Res. 728, 1-6, 1996.

(16) Dawson V.L. and Dawson T.M. Free radicals and neuronal cell death. Cell Death and Differentiation 3, 71-78, 1996.

(17) Pillot T., Drouet B., Queille S., Labeur C., Vandekerckhove J., Rosseneu M., Pincon-Raymond M. and Chambaz J.
The nonfibrillar amyloid _-peptide induces apoptotic neuronal cell death: Involvement of its c-terminal fusogenic domain. J. Neurochem. 73, 1626-1634, 1999.

(18) Herbison A.E., Augood S.J. and Slmonian S.X. Regulation of GABA transport activity and mRNA expression
by estrogen in rat preoptic ares. J. Neurosci. 15, 8302-8309, 1995.



References 2


1. Chartier-Harlin,M.C. et al. Early-onset Alzheimer's disease caused bymutations at codon precursor protein gene. Nature 353, 844-846 (1991).

2. Sherrington,R.et al. Cloning of a gene bearing missense mutations inearly-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).

3. Rogaev,E.I. et al. Familial Alzheimer's disease in kindreds withmissense mutations in a gene on chromosome 1 related to the Alzheimer'sdisease type 3 gene. Nature 376, 775-778 (1995).

4. Borchelt,D.R. et al. Familial Alzheimer's disease-linked presenilin 1variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17,1005-1013 (1996).

5. Duff,K. et al. Increased amyloid beta42 (43) in brains of miceexpressing mutant presenilin 1. Nature 383, 710-713 (1996).

6. Nakano,Y.et al. Accumulation of murine amyloid beta42 with a gene-dosagedependent manner in PS1 'knock-in' mice. Eur.J.Neurosci. 11, 2577-2581(1999).

7. Iwatsubo,T. et al. Visualization of A?42 (43) and A?40 in senileplaques with end-specific A?monoclonals: evidence that an initiallydeposited species is A?42 (43). Neuron 13, 45-53 (1994).

8. Scheuner,D. et al. Secreted amyloid beta-protein similar to that in thesenile plaques of Alzheimer's disease is increased in vivo by thepresenilin a and 2
and APP mutations linked to familial Alzheimer'sdisease. Nature Med. 2, 864-870 (1996).

9. Wong,P.C. et al. Presenilin 1 is required for Notch and Dll1 expressionin the paraxial mesoderm. Nature 387, 288-292 (1997).

10. Davis,J.A. et al. An Alzheimer's disease-linked PS1 variant rescues thedevelopmental abnormalities of PS1-deficient embryos. Neuron 20, 603-609(1998).

11. De Strooper,B. et al. Deficiency of presenilin-1 inhibits the normalcleavage of amyloid precursor protein. Nature 391, 387-390 (1998).

12. Wolfe,M.S. et al. Two transmembrane aspartates in presenilin-1required for presenilin endoproteolysis and gamma-secretase activity.Nature 398, 513-517 (1999).

13. Guo,Q.et al. Alzheimer's presenilin mutation sensitizes neural cells toapoptosis induced by trophic factor withdrawal
and amyloid?-peptide:involvement of calcium and oxyradicals. J.Neurosci. 17, 4212-4222 (1997).

14. Guo,Q.et al. Increased vulnerability of hippocampal neurons toexcitotoxic necrosis in presenilin-1 mutant knock-in mice. Nature Med. 5,101-106 (1999).

15. Sidrauski,C.et al. The unfolded protein response: an intracellularsignalling pathway with many surprising features. Trends in Cell Biol. 8,245-249 (1998).

16. Tirasophon,W. et al. A stress response pathway from the endoplasmicreticulum to the nucleus requires
a novel bifunctional proteinkinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12,1812-1824(1998).

17. Wang,X-Z.et al. Cloning of mammalian Ire1 reveals diversity in the ERstress responses. EMBO J. 17, 5708-5717 (1998).

18. Katayama, T. et al. Presenilin-1 mutations downregulate the signalling pathway of unfolded protein response. Nature Cell Biol. in press (1999).

19. Iwatsubo, T. et al. Purification and characterization of Lewy bodiesfrom the brains of patients with diffuse Lewy body disease. Am.J.Pathol.148, 1517-1529 (1996).

20. DiFiglia,M. et al. Aggregation of huntingtin in neuronal intranuclearinclusions and dystrophic neurites in brain.  Science 277, 1990-1993(1997).



References 3

1) Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S., Ishizaki, Y., and Jacobson, M. D. (1993)
Programmed cell death and the control of cell survival: lessons from the nervous system. Science, 262:695-700.

2) Purves, D.(1988) "Body and Brain" Harverd University Press.

3) Levi-Montalcini, R. And Angeletti, P. (1968)
Nerve growth factor, Pysiol. Rev., 48:534-569.

4) Cohen, S. And Levi-Montalcini, R. (1956)
A nerve growth-stimulating factor isolated from snake venom. Proc. Natl. Acad Sci. USA, 42:571-574.

5) Johnson, E. M., Gorin, P. D., Brandeis, L. D. And Pearson, J. (1980)
Science, 210:916-918.

6) Smeyne, R. J., Klein, R., Schnapp, A., Long, L. K., Bryant, S., Lewin, S. A. and Barbacid, M. (1994)
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF. Nature, 368:246-248.

7) Davies, A. M., Enokido, Y. and Wyatt, S.(1999)
Paradigms of neurotrophic factor action in regulating neuronal survival in the developing nervous system. Taniguchi Symposium, in press.

8) Davies, A. M., Bandtlow, C., Heumann, R., Korsching, S., Rohrer, H. And Thoenen, H. (1988)
Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor. Nature, 326:353-358.

9) Wyatt, S. And Davies, A. M.(1993)
Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons. Development, 119:635-648.

10) Buchman, V. L., and Davies, A. M.(1993)
Different neurotrophins are expressedand act in a developmental sequence to promote the survival of embryonic sensory neurons. Development, 118: 989-1001.

11) Davies, A. M. (1997)
Neurotrophin switching: where does it stand? Curr. Opin. Neurobiol.,7:110-118.

12) Verdi, J. M. And Anderson, D. J. (1994)
Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts.Neuron, 13:1359-1372.

13) Wang, H. And Tessier-Lavigne, M.(1999)
En passant neurotrophic action of and intermediate axonal target in the developing mammalian CNS. Nature, 401;765-769.

14) Davies , A. M. and Wright, E. M. (1995) Neurotrophin autocrine loops. Curr. Biol., 5:723-726.

15) ElShamy, W. M., Fridvall, L. K. and Ernfors, P.(1998)
Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3.Neuron, 21:1003-15

16) Enokido, Y., Wyatt, S. and Davies, A. M. (1999)
Developmental changes in the response of trigeminal neurons to neurotrophins: influence of birthdate and the ganglion environment. Development, 126:4365-4373.

17) Ma, Q., Fode, C., Guillemot, F. and Anderson, D. J.(1999)
NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes & Dev., 13:1717-1728.

18) Ma, Q., Chen, Z., del Barco Barrantes, I., de la Pompa, J. L. and Anderson, D. J. (1998)
Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron, 20:469-82

19) Fode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C. and Guillemot, F. (1998)
The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron, 20:483-94

20) O'Connor, R. and Tessier-Lavigne, M.(1999)
Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons. Neuron, 24:165-178.

21) Lumsden, A. G., and Davies, A. M. (1983)
Earliest sinsory nerve fibers are guided to peripheral targets by attractants other than nerve growth factor. Nature,306:786-788.

22) Tessier-Lavigne, M., and Placzek, M. (1991)
Target attraction: are developing axons guided by chemotropism? Trends Neurosci., 14:303-310.

23) Blasschke, A. J., Staley, K. and Chun, J.(1996)
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development, 122:1165-1174.





Dr. HIROYUKI OHYAMA(Ph.D) in 1995.

Age-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori

Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan

 

Age-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori

Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan

Dr. HIROYUKI OHYAMA(Ph.D) in 1995.


sohhaku OHYAMA memorial
Oriental Medicine Museum